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Article

Increased expression of brain-derived neurotrophic factor preserves retinal function and slows cell death from rhodopsin mutation or oxidative damage.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 May 2003

Okoye Godwin, Zimmer Joelle, Sung Jennifer, Gehlbach Peter, Deering Tye, Nambu Hiroyuki, Hackett Sean, Melia Michele, Esumi Noriko, Zack Donald J, Campochiaro Peter A

Abstract excerpt

There are no effective treatments for inherited retinal degenerations, which are prevalent causes of visual disability. Several proteins promote the survival of various types of neurons, and increasing expression of one or more of these survival factors is a promising strategy for a new treatment. Studies examining the effects of intravitreous injections of brain-derived neurotrophic factor (BDNF) in models of...

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Identifiers

PMID: 12764104
PMCID: PMC6741081

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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