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Article

Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice.

Journal of neurobiology - 1 Mar 2006

Rios Maribel, Lambe Evelyn K, Liu Rongjian, Teillon Sarah, Liu JinHong, Akbarian Schahram, Roffler-Tarlov Suzanne, Jaenisch Rudolf, Aghajanian George K

Abstract excerpt

BDNF is thought to provide critical trophic support for serotonin neurons. In order to determine postnatal effects of BDNF on the serotonin system, we examined a line of conditional mutant mice that have normal brain content of BDNF during prenatal development but later depletion of this neurotrophin in the postnatal period. These mice show a behavioral phenotype that suggests serotonin dysregulation. However, as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16408297
DOI: 10.1002/neu.20233

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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