Expression of monomorphic and polymorphic N-acetyltransferases in human colon.

doi:10.1016/0006-2952(94)90493-6

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Article

Expression of monomorphic and polymorphic N-acetyltransferases in human colon.

Biochemical pharmacology - 2 Mar 1994

Ilett K F, Ingram D M, Carpenter D S, Teitel C H, Lang N P, Kadlubar F F, Minchin R F

Abstract excerpt

The metabolism of sulfamethazine (SMZ) and p-aminobenzoic acid (PABA) by N-acetyltransferase (NAT) was measured in human colorectal cytosols from 12 slow and 11 rapid acetylators whose genotype was determined independently by a specific polymerase chain reaction. SMZ metabolism was significantly...

Topics

4-Aminobenzoic Acid
Acetylation
Acetyltransferases
Aged
Base Sequence
Colon
Female
Gene Expression
Humans
In Vitro Techniques
Intestinal Mucosa
Male
Middle Aged
Molecular Sequence Data
Phenotype
Polymerase Chain Reaction
Polymorphism, Genetic
RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 8135868
DOI: 10.1016/0006-2952(94)90493-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8135868-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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