Expression of monomorphic arylamine N-acetyltransferase (NAT1) in human leukocytes.

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Article

Expression of monomorphic arylamine N-acetyltransferase (NAT1) in human leukocytes.

The Journal of pharmacology and experimental therapeutics - 1 Dec 1991

Cribb A E, Grant D M, Miller M A, Spielberg S P

Abstract excerpt

The expression of arylamine N-acetyltransferase (NAT) in leukocytes was investigated using p-aminobenzoic acid (PABA) and sulfamethazine (SMZ), substrates which are preferentially acetylated by the monomorphic NAT1 and polymorphic NAT2 enzymes, respectively. Activity towards both substrates was detected in mononuclear leukocytes (MNL; preparation containing approximately 80% lymphocytes), monocytes and...

Topics

4-Aminobenzoic Acid
Acetyl Coenzyme A
Acetylation
Adult
Aged
Arylamine N-Acetyltransferase
Caffeine
Female
Humans
Kinetics
Leukocytes, Mononuclear
Liver

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Monocytes

Neutrophils

Phenotype

Sulfamethazine

Source

Open in PubMed

Identifiers

PMID: 1762071

Genes

NAT1
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1762071-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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