Article
Expression of monomorphic arylamine N-acetyltransferase (NAT1) in human leukocytes.
The Journal of pharmacology and experimental therapeutics - 1 Dec 1991
Cribb A E, Grant D M, Miller M A, Spielberg S P
Abstract excerpt
The expression of arylamine N-acetyltransferase (NAT) in leukocytes was investigated using p-aminobenzoic acid (PABA) and sulfamethazine (SMZ), substrates which are preferentially acetylated by the monomorphic NAT1 and polymorphic NAT2 enzymes, respectively. Activity towards both substrates was detected in mononuclear leukocytes (MNL; preparation containing approximately 80% lymphocytes), monocytes and...
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