Article
Expression of arylamine N-acetyltransferase in human intestine.
Gut - 1 Mar 1998
Hickman D, Pope J, Patil S D, Fakis G, Smelt V, Stanley L A, Payton M, Unadkat J D, Sim E
Abstract excerpt
BACKGROUND: Arylamine N-acetyltransferases in humans (NAT1 and NAT2) catalyse the acetylation of arylamines including food derived heterocyclic arylamine carcinogens. Other substrates include the sulphonamide 5-aminosalicylic acid (5-ASA), which is an NAT1 specific substrate; N-acetylation of 5-ASA is a major route of metabolism. NAT1 and NAT2 are both polymorphic. AIMS: To investigate NAT expression in...
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