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Article

Human acetylator genotype: relationship to colorectal cancer incidence and arylamine N-acetyltransferase expression in colon cytosol.

Archives of toxicology - 1 Jan 1993

Rodriguez J W, Kirlin W G, Ferguson R J, Doll M A, Gray K, Rustan T D, Lee M E, Kemp K, Urso P, Hein D W

Abstract excerpt

Polymorphic expression of arylamine N-acetyltransferase (EC 2.3.1.5) may be a differential risk factor in metabolic activation of arylamine carcinogens and susceptibility to cancers related to arylamine exposures. Human epidemiological studies suggest that rapid acetylator phenotype may be associated with higher incidences of colorectal cancer. We used restriction fragment length polymorphism analysis to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 7902079
DOI: 10.1007/BF01969914

Genes

NAT2
NAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Human acetylator genotype: relationship to colorectal cancer incidence and arylamine N-acetyltransferase expression in colon cytosol.PMID 7902079Read ↗

Acetylator genotype-dependent expression of arylamine N-acetyltransferase in human colon cytosol from non-cancer and colorectal cancer patients.Semantic proximity Read ↗

Acetylator genotype-dependent expression of arylamine N-acetyltransferase and N-hydroxyarylamine O-acetyltransferase in Syrian inbred hamster intestine and colon. Identity with the hepatic acetylation polymorphism.Semantic proximity Read ↗

Metabolic activation of N-hydroxy-2-aminofluorene and N-hydroxy-2-acetylaminofluorene by monomorphic N-acetyltransferase (NAT1) and polymorphic N-acetyltransferase (NAT2) in colon cytosols of Syrian hamsters congenic at the NAT2 locus.Semantic proximity Read ↗

N-acetyltransferase polymorphisms and colorectal cancer: a HuGE review.Semantic proximity Read ↗

Expression of arylamine N-acetyltransferase in human intestine.Semantic proximity Read ↗

Expression of monomorphic and polymorphic N-acetyltransferases in human colon.Semantic proximity Read ↗

Polymorphisms of N-acetyltransferase genes.Semantic proximity Read ↗

Role of acetylation in colorectal cancer.Semantic proximity Read ↗

N-acetyltransferase 2 (NAT2) genotype and colorectal carcinoma: risk variability according to tumour site?Semantic proximity Read ↗

Molecular genetics and function of NAT1 and NAT2: role in aromatic amine metabolism and carcinogenesis.Semantic proximity Read ↗

Identification and kinetic characterization of acetylator genotype-dependent and -independent arylamine carcinogen N-acetyltransferases in hamster bladder cytosol.Semantic proximity Read ↗

Cloning, expression, and functional characterization of two mutant (NAT2(191) and NAT2(341/803)) and wild-type human polymorphic N-acetyltransferase (NAT2) alleles.Semantic proximity Read ↗

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