Article
Human acetylator genotype: relationship to colorectal cancer incidence and arylamine N-acetyltransferase expression in colon cytosol.
Archives of toxicology - 1 Jan 1993
Rodriguez J W, Kirlin W G, Ferguson R J, Doll M A, Gray K, Rustan T D, Lee M E, Kemp K, Urso P, Hein D W
Abstract excerpt
Polymorphic expression of arylamine N-acetyltransferase (EC 2.3.1.5) may be a differential risk factor in metabolic activation of arylamine carcinogens and susceptibility to cancers related to arylamine exposures. Human epidemiological studies suggest that rapid acetylator phenotype may be associ...
Topics
- Acetylation
- Aging
- Alleles
- Arylamine N-Acetyltransferase
- Base Sequence
- Colon
- Colorectal Neoplasms
- Cytosol
- Female
- Gene Frequency
- Genotype
- Humans
- Incidence
- Male
- Middle Aged