Mutation, cell kinetics, and subpopulations at risk for colon cancer in the United States.

doi:10.1016/s0027-5107(98)00067-0

Back to search

Article

Mutation, cell kinetics, and subpopulations at risk for colon cancer in the United States.

Mutation research - 25 May 1998

Herrero-Jimenez P, Thilly G, Southam P J, Tomita-Mitchell A, Morgenthaler S, Furth E E, Thilly W G

Abstract excerpt

We have extended the algebraic models for cancer initiation and progression developed by Nordling, Armitage-Doll and Knudson-Moolgavkar to include the effect of cell turnover rate in normal tissue, stochastic growth of preneoplastic adenomas, and the general case wherein a subfraction of the popu...

Topics

Adenoma
Apoptosis
Cell Cycle
Cell Division
Colonic Neoplasms
Computer Simulation
Disease Progression
Genetics, Population
Humans
Models, Statistical
Mutation
Risk Assessment
Survival Rate
Tissue Survival

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.