Article
Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids.
Proceedings of the National Academy of Sciences of the United States of America - 21 Mar 2017
Fumagalli Arianna, Drost Jarno, Suijkerbuijk Saskia J E, van Boxtel Ruben, de Ligt Joep, Offerhaus G Johan, Begthel Harry, Beerling Evelyne, Tan Ee Hong, Sansom Owen J, Cuppen Edwin, Clevers Hans, van Rheenen Jacco
Abstract excerpt
In the adenoma-carcinoma sequence, it is proposed that intestinal polyps evolve through a set of defined mutations toward metastatic colorectal cancer (CRC). Here, we dissect this adenoma-carcinoma sequence in vivo by using an orthotopic organoid transplantation model of human colon organoids engineered to harbor different CRC mutation combinations. We demonstrate that sequential accumulation of oncogenic...
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