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Article

Growth-factor-independence and invasive properties of colorectal carcinoma cells.

International journal of cancer - 21 Jan 1992

Williams N N, Györfi T, Iliopoulos D, Herlyn D, Greenstein D, Linnenbach A J, Daly J M, Jensen P, Rodeck U, Herlyn M

Abstract excerpt

During serial passage of the colorectal carcinoma cell line SW1116 in athymic nude mice, we selected 2 variants that metastasized to the lungs and liver. The metastatic capacity of these in vivo variant cell lines was associated with their ability to (1) grow under growth-factor-deprived conditions, (2) invade and transgress a reconstructed basement membrane with high effectiveness, and (3) produce higher...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 1730521
DOI: 10.1002/ijc.2910500218

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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