Article
Growth-factor-independence and invasive properties of colorectal carcinoma cells.
International journal of cancer - 21 Jan 1992
Williams N N, Györfi T, Iliopoulos D, Herlyn D, Greenstein D, Linnenbach A J, Daly J M, Jensen P, Rodeck U, Herlyn M
Abstract excerpt
During serial passage of the colorectal carcinoma cell line SW1116 in athymic nude mice, we selected 2 variants that metastasized to the lungs and liver. The metastatic capacity of these in vivo variant cell lines was associated with their ability to (1) grow under growth-factor-deprived conditio...
Topics
- Animals
- Cell Division
- Colorectal Neoplasms
- Growth Substances
- Humans
- Liver Neoplasms, Experimental
- Lung Neoplasms
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Neoplasm Invasiveness
- Neoplasm Metastasis
- Neoplasm Transplantation
- Phenotype
- Tumor Cells, Cultured