Article
Phenotype alteration in colon carcinoma cells: effect of in vivo passage?
In vitro cellular & developmental biology : journal of the Tissue Culture Association - 1 May 1991
Maley M A, House A K, Jenkyn D J, Sterrett G
Abstract excerpt
A panel of rat colon adenocarcinoma cell lines (the Per series) were used to investigate the phenotype and karyotype changes induced by in vivo passage in the subcutis of athymic nude mice. One poorly and one well-differentiated tumor cell line were serially passaged through the athymic nude mouse and then back to the syngeneic rat host. Each of the primary and xenograft cell lines expressed fetal crypt cell...
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