The timSL mutant of the Drosophila rhythm gene timeless manifests allele-specific interactions with period gene mutants.

doi:10.1016/s0896-6273(00)80223-8

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Article

The timSL mutant of the Drosophila rhythm gene timeless manifests allele-specific interactions with period gene mutants.

Neuron - 1 Nov 1996

Rutila J E, Zeng H, Le M, Curtin K D, Hall J C, Rosbash M

Abstract excerpt

To identify new components of the Drosophila circadian clock, we screened chemically mutagenized flies for suppressors or enhancers of the long periods characteristic of the period (per) mutant allele perL. We isolated a novel mutant that maps to the rhythm gene timeless (tim). This novel allele,...

Topics

Alleles
Animals
Chromosome Mapping
Circadian Rhythm
Drosophila
Drosophila Proteins
Enhancer Elements, Genetic
Ethyl Methanesulfonate
Female
Gene Expression
Genes, Insect
Genetic Testing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mutagenesis

Mutagens

Nuclear Proteins

Period Circadian Proteins

Phenotype

Source

Open in PubMed

Identifiers

PMID: 8938124
DOI: 10.1016/s0896-6273(00)80223-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8938124-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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The timSL mutant of the Drosophila rhythm gene timeless manifests allele-specific interactions with period gene mutants.PMID 8938124Read ↗

The timSL mutant affects a restricted portion of the Drosophila melanogaster circadian cycle.Semantic proximity Read ↗

Isolation of timeless by PER protein interaction: defective interaction between timeless protein and long-period mutant PERL.Semantic proximity Read ↗

Post-translational regulation and nuclear entry of TIMELESS and PERIOD are affected in new timeless mutant.Semantic proximity Read ↗

Isolation and analysis of six timeless alleles that cause short- or long-period circadian rhythms in Drosophila.Semantic proximity Read ↗

Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless.Semantic proximity Read ↗

A TIMELESS-independent function for PERIOD proteins in the Drosophila clock.Semantic proximity Read ↗

double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation.Semantic proximity Read ↗

TIMELESS is an important mediator of CK2 effects on circadian clock function in vivo.Semantic proximity Read ↗

Cooperative interaction between phosphorylation sites on PERIOD maintains circadian period in Drosophila.Semantic proximity Read ↗

Block in nuclear localization of period protein by a second clock mutation, timeless.Semantic proximity Read ↗

PER-TIM interactions with the photoreceptor cryptochrome mediate circadian temperature responses in Drosophila.Semantic proximity Read ↗

Short-period mutations of per affect a double-time-dependent step in the Drosophila circadian clock.Semantic proximity Read ↗

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