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Article

Light-dependent sequestration of TIMELESS by CRYPTOCHROME.

Science (New York, N.Y.) - 23 Jul 1999

Ceriani M F, Darlington T K, Staknis D, Más P, Petti A A, Weitz C J, Kay S A

Abstract excerpt

Most organisms have circadian clocks consisting of negative feedback loops of gene regulation that facilitate adaptation to cycles of light and darkness. In this study, CRYPTOCHROME (CRY), a protein involved in circadian photoperception in Drosophila, is shown to block the function of PERIOD/TIMELESS (PER/TIM) heterodimeric complexes in a light-dependent fashion. TIM degradation does not occur under these...

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Source

Identifiers

PMID: 10417378
DOI: 10.1126/science.285.5427.553

Genes

TIMELESS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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Light-dependent sequestration of TIMELESS by CRYPTOCHROME.PMID 10417378Read ↗

Roles of the two Drosophila CRYPTOCHROME structural domains in circadian photoreception.Semantic proximity Read ↗

Circadian photoreception in Drosophila: functions of cryptochrome in peripheral and central clocks.Semantic proximity Read ↗

Photic signaling by cryptochrome in the Drosophila circadian system.Semantic proximity Read ↗

PER-TIM interactions with the photoreceptor cryptochrome mediate circadian temperature responses in Drosophila.Semantic proximity Read ↗

A constitutively active cryptochrome in Drosophila melanogaster.Semantic proximity Read ↗

Mitochondrial inhibitors reveal roles of specific respiratory chain complexes in CRY-dependent degradation of TIM.Semantic proximity Read ↗

Disruption of Cryptochrome partially restores circadian rhythmicity to the arrhythmic period mutant of Drosophila.Semantic proximity Read ↗

Cryptochrome-Timeless structure reveals circadian clock timing mechanismsSemantic proximity Read ↗

Clock-gated photic stimulation of timeless expression at cold temperatures and seasonal adaptation in Drosophila.Semantic proximity Read ↗

Exquisite light sensitivity of Drosophila melanogaster cryptochrome.Semantic proximity Read ↗

Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless.Semantic proximity Read ↗

A TIMELESS-independent function for PERIOD proteins in the Drosophila clock.Semantic proximity Read ↗

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