Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless.

doi:10.1126/science.8128246

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Article

Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless.

Science (New York, N.Y.) - 18 Mar 1994

Sehgal A, Price J L, Man B, Young M W

Abstract excerpt

Eclosion, or emergence of adult flies from the pupa, and locomotor activity of adults occur rhythmically in Drosophila melanogaster, with a circadian period of about 24 hours. Here, a clock mutation, timeless (tim), is described that produces arrhythmia for both behaviors. The effects of tim on b...

Topics

Animals
Biological Clocks
Chromosome Mapping
Circadian Rhythm
Drosophila Proteins
Drosophila melanogaster
Gene Expression Regulation
Genes, Insect
Metamorphosis, Biological
Motor Activity
Mutagenesis, Insertional
Mutation
Nuclear Proteins
Period Circadian Proteins
RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 8128246
DOI: 10.1126/science.8128246

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8128246-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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