Article
The molecular genetics of Alzheimer's disease.
Molecular neurobiology - 1 Jan 1994
Mullan M, Crawford F
Abstract excerpt
The major pathological characteristic of Alzheimer's disease (AD) is the abnormal deposition of beta-amyloid peptide (A beta) in the brain. In some early onset cases, the disease develops because of mutations in the gene coding for beta-amyloid precursor protein (beta APP). However, the majority of AD families in the early onset subgroup are linked to a locus on chromosome 14. The genetic analysis and age of...
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