Molecular genetics of Alzheimer's disease.

doi:10.1016/s0006-3223(99)00301-7

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Article

Molecular genetics of Alzheimer's disease.

Biological psychiatry - 1 Feb 2000

St George-Hyslop P H

Abstract excerpt

Application of genetic paradigms to Alzheimer's disease (AD) has led to confirmation that genetic factors play a role in this disease. Additionally, researchers now understand that AD is genetically heterogeneous and that some genetic isoforms appear to have similar or related biochemical consequences. Genetic epidemiologic studies indicate that first-degree relatives of AD probands have an age-dependent risk for...

Topics

Aged
Alzheimer Disease
Amyloid beta-Peptides
Amyloid beta-Protein Precursor
Animals
Chromosome Aberrations
Chromosome Disorders
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 21
Disease Models, Animal
Genes, Dominant
Genetic Predisposition to Disease
Humans
Membrane Proteins
Mutation, Missense
Peptide Fragments
Presenilin-1

Source

Open in PubMed

Identifiers

PMID: 10682216
DOI: 10.1016/s0006-3223(99)00301-7

Genes

APP
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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