Molecular genetics of Alzheimer's disease.

Abstract excerpt

Four genes have thus far been implicated in the etiology of Alzheimer's disease (AD). A series of mutations in the amyloid precursor protein (APP) gene on chromosome 21, which cause disease with a typical onset of 55 years of age, have been described. These include mutations at APP670/671, APP692, and APP717. The epsilon 4 allele of the apolipoprotein E (ApoE) gene on chromosome 19 is positively associated with...

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