The developmental role of Agouti in color pattern evolution.

doi:10.1126/science.1200684

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

The developmental role of Agouti in color pattern evolution.

Science (New York, N.Y.) - 25 Feb 2011

Manceau Marie, Domingues Vera S, Mallarino Ricardo, Hoekstra Hopi E

Abstract excerpt

Animal color patterns can affect fitness in the wild; however, little is known about the mechanisms that control their formation and subsequent evolution. We took advantage of two locally camouflaged populations of Peromyscus mice to show that the negative regulator of adult pigmentation, Agouti, also plays a key developmental role in color pattern evolution. Genetic and functional analyses showed that...

Topics

Agouti Signaling Protein
Alleles
Animals
Biological Evolution
Body Patterning
Cell Differentiation
Cell Proliferation
Dermis
Embryo, Mammalian
Epidermal Cells
Epidermis
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fetus

Gene Expression

Gene Expression Regulation, Developmental

Hair Color

Hair Follicle

Male

Source

Open in PubMed

Identifiers

PMID: 21350176
DOI: 10.1126/science.1200684

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The developmental role of Agouti in color pattern evolution.PMID 21350176Read ↗

The agouti gene: turned on to yellow.Semantic proximity Read ↗

Differences in dorsal and ventral pigmentation result from regional expression of the mouse agouti gene.Semantic proximity Read ↗

An enhancer of Agouti contributes to parallel evolution of cryptically colored beach mice.Semantic proximity Read ↗

Molecular analysis of reverse mutations from nonagouti (a) to black-and-tan (a(t)) and white-bellied agouti (Aw) reveals alternative forms of agouti transcripts.Semantic proximity Read ↗

Evolution in action: highlighting a role for the Agouti gene in development?Semantic proximity Read ↗

Aberrant regulation of the Agouti pigment pattern in the viable yellow mouse.Semantic proximity Read ↗

Adaptive variation in beach mice produced by two interacting pigmentation genes.Semantic proximity Read ↗

Differential expression of a new dominant agouti allele (Aiapy) is correlated with methylation state and is influenced by parental lineage.Semantic proximity Read ↗

The role of isoforms in the evolution of cryptic coloration in Peromyscus mice.Semantic proximity Read ↗

Genetics, development and evolution of adaptive pigmentation in vertebrates.Semantic proximity Read ↗

Molecular characterization of the mouse agouti locus.Semantic proximity Read ↗

CRISPR/Cas9-mediated genome editing in wild-derived mice: generation of tamed wild-derived strains by mutation of the a (nonagouti) gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.