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Article

Evolution of MHC genetic diversity: a tale of incest, pestilence and sexual preference.

Trends in genetics : TIG - 1 Dec 1993

Potts W K, Wakeland E K

Abstract excerpt

Evidence from the house mouse (Mus) suggests that the extreme diversity of genes of the major histocompatibility complex (MHC) results from three different forms of selection involving infectious disease (pestilence), inbreeding (incest) and MHC-based mating (sexual) preferences. MHC-based disassortative mating preferences are presumed to have evolved because they reduce homozygosity throughout the genome, and...

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Identifiers

PMID: 8122307
DOI: 10.1016/0168-9525(93)90103-o

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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