Evolution of MHC genetic diversity: a tale of incest, pestilence and sexual preference.

doi:10.1016/0168-9525(93)90103-o

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Article

Evolution of MHC genetic diversity: a tale of incest, pestilence and sexual preference.

Trends in genetics : TIG - 1 Dec 1993

Potts W K, Wakeland E K

Abstract excerpt

Evidence from the house mouse (Mus) suggests that the extreme diversity of genes of the major histocompatibility complex (MHC) results from three different forms of selection involving infectious disease (pestilence), inbreeding (incest) and MHC-based mating (sexual) preferences. MHC-based disass...

Topics

Animals
Biological Evolution
Genetic Variation
Inbreeding
Infections
Major Histocompatibility Complex
Mice
Selection, Genetic
Sexual Behavior, Animal

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