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Article

How pathogens drive genetic diversity: MHC, mechanisms and misunderstandings.

Proceedings. Biological sciences - 7 Apr 2010

Spurgin Lewis G, Richardson David S

Abstract excerpt

Major histocompatibility complex (MHC) genes have been put forward as a model for studying how genetic diversity is maintained in wild populations. Pathogen-mediated selection (PMS) is believed to generate the extraordinary levels of MHC diversity observed. However, establishing the relative importance of the three proposed mechanisms of PMS (heterozygote advantage, rare-allele advantage and fluctuating...

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Identifiers

PMID: 20071384
DOI: 10.1098/rspb.2009.2084
PMCID: PMC2842774

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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