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Article

Does intra-individual major histocompatibility complex diversity keep a golden mean?

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 12 Jan 2009

Woelfing Benno, Traulsen Arne, Milinski Manfred, Boehm Thomas

Abstract excerpt

An adaptive immune response is usually initiated only if a major histocompatibility complex (MHC) molecule presents pathogen-derived peptides to T-cells. Every MHC molecule can present only peptides that match its peptide-binding groove. Thus, it seems advantageous for an individual to express many different MHC molecules to be able to resist many different pathogens. However, although MHC genes are the most...

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Identifiers

PMID: 18926972
DOI: 10.1098/rstb.2008.0174
PMCID: PMC2666699

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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