Article
The role of infectious disease, inbreeding and mating preferences in maintaining MHC genetic diversity: an experimental test.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Nov 1994
Potts W K, Manning C J, Wakeland E K
Abstract excerpt
In house mice, and probably most mammals, major histocompatibility complex (MHC) gene products influence both immune recognition and individual odours in an allele-specific fashion. Although it is generally assumed that some form of pathogen-driven balancing selection is responsible for the unprecedented genetic diversity of MHC genes, the MHC-based mating preferences observed in house mice are sufficient to...
Topics
- Animals
- Communicable Diseases
- Female
- Genetic Variation
- Humans
- Inbreeding
- Major Histocompatibility Complex
- Male
- Mice
- Sexual Behavior, Animal