Article
Population biology of antigen presentation by MHC class I molecules.
Science (New York, N.Y.) - 5 Apr 1996
Parham P, Ohta T
Abstract excerpt
In principle, the function of major histocompatibility complex (MHC) molecules is simple: to bind a peptide and engage a T cell. In practice, placing this function within the context of the immune response begs questions of population biology; How does the immune response emerge from the interact...
Topics
- Amino Acid Sequence
- Antigen Presentation
- Antigens
- Evolution, Molecular
- Gene Frequency
- Genes, MHC Class I
- Genetic Variation
- Genetics, Population
- Histocompatibility Antigens Class I
- Humans
- Indians, North American
- Indians, South American
- Infections
- Molecular Sequence Data
- Polymorphism, Genetic
- Recombination, Genetic
- Selection, Genetic