Article
Population biology of antigen presentation by MHC class I molecules.
Science (New York, N.Y.) - 5 Apr 1996
Parham P, Ohta T
Abstract excerpt
In principle, the function of major histocompatibility complex (MHC) molecules is simple: to bind a peptide and engage a T cell. In practice, placing this function within the context of the immune response begs questions of population biology; How does the immune response emerge from the interactions among populations of peptides, T cells and MHC molecules? Within a population of vertebrates, how does MHC...
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