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Article

Ex vivo characterization of allo-MHC-restricted T cells specific for a single MHC-peptide complex.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2006

Pittet Mikaël J, Gati Asma, Le Gal Frederic-Anne, Bioley Gilles, Guillaume Philippe, de Smedt Magda, Plum Jean, Speiser Daniel E, Cerottini Jean-Charles, Dietrich Pierre-Yves, Romero Pedro, Zippelius Alfred

Abstract excerpt

Alloreactive T cells are thought to be a potentially rich source of high-avidity T cells with therapeutic potential since tolerance to self-Ags is restricted to self-MHC recognition. Given the particularly high frequency of alloreactive T cells in the peripheral immune system, we used numerous MHC class I multimers to directly visualize and isolate viral and tumor Ag-specific alloreactive CD8 T cells. In fact,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 16455990
DOI: 10.4049/jimmunol.176.4.2330

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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