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Article

Determinants of polyreactivity in a large panel of recombinant human antibodies from HIV-1 infection

1 Jul 1996

Abstract excerpt

A considerable part of the Ab repertoire is given over to polyreactive Abs capable of interacting with multiple antigenic species. Neither the function of these Abs nor the molecular basis for their activity is known. To address the latter problem, we have compared the amino acid sequences of a large panel (n = 70) of polyreactive human monoclonal Fab fragments and conducted a series of engineering experiments on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 8752924
DOI: 10.4049/jimmunol.157.2.739

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