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Article

Structural insights into conformational flexibility at the peripheral site and within the active center gorge of AChE.

Chemico-biological interactions - 15 Dec 2005

Bourne Yves, Radić Zoran, Kolb Hartmuth C, Sharpless K Barry, Taylor Palmer, Marchot Pascale

Abstract excerpt

The peripheral anionic site on acetylcholinesterase (AChE), located at the active site gorge entry, encompasses overlapping binding sites for allosteric activators and inhibitors. Yet the molecular mechanisms coupling this site to the active center at the base of the gorge to modulate catalysis remain unclear. Crystal structures of mAChE bound with decidium, propidium and gallamine unveiled new determinants...

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Identifiers

PMID: 16259971
DOI: 10.1016/j.cbi.2005.10.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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