Hypomethylation of CCGG sites in the 3' region of H-ras protooncogene is frequent and is associated with H-ras allele loss in non-small cell lung cancer.

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Article

Hypomethylation of CCGG sites in the 3' region of H-ras protooncogene is frequent and is associated with H-ras allele loss in non-small cell lung cancer.

Cancer research - 1 Mar 1994

Vachtenheim J, Horáková I, Novotná H

Abstract excerpt

The methylation of MspI/HpaII sites flanking a variable tandem repeat in the 3' region of the c-Ha-ras protooncogene was analyzed in 74 DNA samples of non-small cell lung carcinomas and control lung tissues. Of 39 informative samples, 7 allelic deletions (18%) were found at the c-Ha-ras locus and...

Topics

Alleles
Base Sequence
Binding Sites
Carcinoma, Non-Small-Cell Lung
Codon
DNA, Neoplasm
Gene Deletion
Genes, ras
Humans
Lung
Lung Neoplasms
Methylation
Molecular Sequence Data
Mutation
Repetitive Sequences, Nucleic Acid

Source

Open in PubMed

Identifiers

PMID: 8118795

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8118795-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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