Article
Allele loss and promoter hypermethylation of VHL, RAR-beta, RASSF1A, and FHIT tumor suppressor genes on chromosome 3p in esophageal squamous cell carcinoma.
Cancer research - 1 Jul 2003
Kuroki Tamotsu, Trapasso Francesco, Yendamuri Sai, Matsuyama Ayumi, Alder Hansjuerg, Mori Masaki, Croce Carlo M
Abstract excerpt
Promoter hypermethylation is an alternative way to inactivate tumor suppressor genes in cancer. Alterations of chromosome 3p are frequently involved in many types of cancer, including esophageal squamous cell carcinoma. Here, we investigated the methylation status and loss of heterozygosity (LOH) of 3p tumor suppressor genes. We examined the promoter methylation status of von Hippel-Lindau disease (VHL), retinoic...
Topics
- Acid Anhydride Hydrolases
- Alleles
- Base Sequence
- Carcinoma, Squamous Cell
- Chromosome Mapping
- Chromosomes, Human, Pair 3
- DNA Methylation
- DNA Primers
- DNA, Neoplasm
- Esophageal Neoplasms
- Genes, Tumor Suppressor
- Humans
- Ligases