Point mutation, allelic loss and increased methylation of c-Ha-ras gene in human hepatocellular carcinoma.

Article

Point mutation, allelic loss and increased methylation of c-Ha-ras gene in human hepatocellular carcinoma.

Hepatology (Baltimore, Md.) - 1 Jan 1991

Ogata N, Kamimura T, Asakura H

Abstract excerpt

Somatic alterations of the c-Ha-ras gene were examined in 21 Japanese patients with hepatocellular carcinoma. Restriction endonuclease analysis by double digestion with MspI and HpaII revealed that DNAs from two of 21 hepatocellular carcinoma tissues were affected by nucleotide substitution at th...

Topics

Adult
Alleles
Carcinoma, Hepatocellular
Chromosome Deletion
Codon
DNA, Neoplasm
DNA, Viral
Female
Genes, ras
Hepatitis B virus
Heterozygote
Humans
Liver Neoplasms
Male
Methylation
Middle Aged
Mutation

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.