Article
Single nucleotide polymorphism at codon 133 of the RASSF1 gene is preferentially associated with human lung adenocarcinoma risk.
Cancer letters - 8 Jul 2006
Kanzaki Hirotaka, Hanafusa Hiroko, Yamamoto Hiromasa, Yasuda Yukiko, Imai Kazue, Yano Masaaki, Aoe Motoi, Shimizu Nobuyoshi, Nakachi Kei, Ouchida Mamoru, Shimizu Kenji
Abstract excerpt
The RASSF1 gene, a putative tumor suppressor gene located on human chromosome 3p21, garners much attention for the frequent allelic loss and gene silencing via promoter hypermethylation in a variety of human malignancies. An association between a single nucleotide polymorphism (SNP) at codon 133 of the RASSF1 gene, encoding either alanine (GCT) or serine (TCT), and human cancer risk remains undefined. We...
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