Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA methylation of coding and non-coding regions of the human H-RAS gene in normal and tumor tissues.

Oncogene - 1 Feb 1992

Borrello M G, Pierotti M A, Tamborini E, Biassoni D, Rizzetti M G, Pilotti S, Della Porta G

Abstract excerpt

To study a possible role of DNA methylation in the regulation of expression of the human H-RAS gene in vivo, 41 samples of different normal tissues and 33 tumors of various histotypes were analysed for DNA methylation. In a subset of normal tissues the RNA expression was also examined. The promoter region of the gene showed the features of a CpG island being CpG rich and unmethylated in all the normal tissues and...

Topics

Alleles
Blotting, Southern
DNA, Neoplasm
Gene Expression Regulation
Genes, ras
Humans
Methylation
Neoplasms
Promoter Regions, Genetic
Proto-Oncogene Proteins p21(ras)
RNA, Messenger

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Restriction Mapping

Source

Identifiers

PMID: 1549348

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1549348-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA methylation of coding and non-coding regions of the human H-RAS gene in normal and tumor tissues.PMID 1549348Read ↗

Hypomethylation of CCGG sites in the 3' region of H-ras protooncogene is frequent and is associated with H-ras allele loss in non-small cell lung cancer.Semantic proximity Read ↗

Frequent hypermethylation of RASSF1A tumour suppressor gene promoter and presence of Merkel cell polyomavirus in small cell lung cancerSemantic proximity Read ↗

[Methylation of the promoter region of the RASSF1A gene, a candidate tumor suppressor, in primary epithelial tumors].Semantic proximity Read ↗

Allele loss and promoter hypermethylation of VHL, RAR-beta, RASSF1A, and FHIT tumor suppressor genes on chromosome 3p in esophageal squamous cell carcinoma.Semantic proximity Read ↗

Diverse DNA methylation statuses at alternative promoters of human genes in various tissues.Semantic proximity Read ↗

Hypermethylation of the cpG island of Ras association domain family 1A (RASSF1A), a putative tumor suppressor gene from the 3p21.3 locus, occurs in a large percentage of human breast cancers.Semantic proximity Read ↗

Epigenetic inactivation of the RAS-effector gene RASSF2 in lung cancers.Semantic proximity Read ↗

A methylated CpG island 3' in the apolipoprotein-E gene does not repress its transcription.Semantic proximity Read ↗

RASSF1A promoter region CpG island hypermethylation in phaeochromocytomas and neuroblastoma tumours.Semantic proximity Read ↗

Hypermethylation of the RASSF1A tumor suppressor gene in Japanese clear cell renal cell carcinoma.Semantic proximity Read ↗

Methylation patterns and K-ras mutations in tumor and paired serum of resected non-small-cell lung cancer patients.Semantic proximity Read ↗

Methylation Status and Expression of Human Telomerase Reverse Transcriptase mRNA in Relation to Hypermethylation of the p16 gene in Colorectal Cancers as Analyzed by Bisulfite PCR-SSCPSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.