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Article

Hypermethylation of the tumor suppressor gene RASSFIA and frequent concomitant loss of heterozygosity at 3p21 in cervical cancers.

International journal of cancer - 10 Jun 2003

Yu Mei Y, Tong Joanna H M, Chan Paul K S, Lee Tin L, Chan Michael W Y, Chan Anthony W H, Lo Kwok W, To Kai F

Abstract excerpt

Loss of heterozygosity (LOH) at chromosome 3p21 is frequent in cervical cancers. The candidate tumor suppressor gene, RASSF1A located at 3p21.3, is found to be inactivated in several major human cancers, implicating its significance in carcinogenesis. We aimed to investigate the status of RASSF1A in cervical cancers. The mutation and methylation status of RASSF1A were analysed in 4 cervical cancer cell lines, 50...

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Identifiers

PMID: 12673680
DOI: 10.1002/ijc.11051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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