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Article

RASSF1A gene inactivation in non-small cell lung cancer and its clinical implication.

International journal of cancer - 10 Aug 2003

Endoh Hideki, Yatabe Yasushi, Shimizu Shigeki, Tajima Kohei, Kuwano Hiroyuki, Takahashi Takashi, Mitsudomi Tetsuya

Abstract excerpt

Methylation-associated inactivation of RASSF1, a putative tumor suppressor identified at 3p21.3, is reported in several cancers. We examined RASSF1 in non-small lung cancer (NSCLC) to search for clinical implications. RT-PCR analysis showed no expression of RASSF1A in 12 of 20 lung cancer cell lines. Loss of expression correlated well with promoter methylation status of these lines. Sequence analysis revealed 2...

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Source

Identifiers

PMID: 12794755
DOI: 10.1002/ijc.11184

Genes

RASSF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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