Human Heat Shock Factors 1 and 2 Are Differentially Activated and Can Synergistically Induce hsp70 Gene Transcription

Abstract excerpt

Two members of the heat shock transcription factor (HSF) family, HSF1 and HSF2, both function as transcriptional activators of heat shock gene expression. However, the inducible DNA-binding activities of these two factors are regulated by distinct pathways. HSF1 is activated by heat shock and other forms of stress, whereas HSF2 is activated during hemin-induced differentiation of human K562 erythroleukemia cells,...