Article
Heat shock factor 1 and heat shock proteins: Critical partners in protection against acute cell injury
1 Jan 2002
Abstract excerpt
OBJECTIVE: Life-threatening conditions cause severe changes in the organization and conformation of macromolecules, creating urgent requirements for protein repair to ensure survival. As molecular chaperones, heat shock proteins (HSP) that have specialized functions in protein folding are now well established to restore homeostasis in cells and organisms. Augmentation of HSP synthesis is tightly regulated by...
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