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AIRAP, a New Human Heat Shock Gene Regulated by Heat Shock Factor 1

26 Feb 2010

Abstract excerpt

Heat shock factor-1 (HSF1) is the central regulator of heat-induced transcriptional responses leading to rapid expression of molecular chaperones that protect mammalian cells against proteotoxic stress. The main targets for HSF1 are specific promoter elements (HSE) located upstream of heat shock genes encoding a variety of heat shock proteins, including HSP70, HSP90, HSP27, and other proteins of the network....

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PMID: 20185824
DOI: 10.1074/jbc.m109.082693

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