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Article

Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans.

15 Aug 1991

Abstract excerpt

The heat shock response is transcriptionally regulated by an evolutionarily conserved protein termed heat shock factor (HSF). We report the purification to homogeneity and the partial peptide sequence of HSF from HeLa cells. The peptide sequence was used to isolate a human cDNA with a predicted open reading frame that has homology to the DNA binding domains of both Saccharomyces cerevisiae and Drosophila HSFs....

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Identifiers

PMID: 1871106
DOI: 10.1073/pnas.88.16.6911

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Research trail→

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Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans.PMID 1871106Read ↗

A Heat Shock-Responsive Domain of Human HSF1 That Regulates Transcription Activation Domain FunctionSemantic proximity Read ↗

The human heat-shock protein family. Expression of a novel heat-inducible HSP70 (HSP70B′) and isolation of its cDNA and genomic DNASemantic proximity Read ↗

AIRAP, a New Human Heat Shock Gene Regulated by Heat Shock Factor 1Semantic proximity Read ↗

Activation of heat shock genes is not necessary for protection by heat shock transcription factor 1 against cell death due to a single exposure to high temperatures.Semantic proximity Read ↗

Identification of a novel class of target genes and a novel type of binding sequence of heat shock transcription factor in Saccharomyces cerevisiae.Semantic proximity Read ↗

Differential recognition of heat shock elements by members of the heat shock transcription factor family.Semantic proximity Read ↗

Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine aggregationSemantic proximity Read ↗

Regulation of Cyclooxygenase-2 Expression by Heat: A Novel Aspect of Heat Shock Factor 1 Function in Human CellsSemantic proximity Read ↗

Multiple functions of Drosophila heat shock transcription factor in vivo.Semantic proximity Read ↗

Human Heat Shock Factors 1 and 2 Are Differentially Activated and Can Synergistically Induce hsp70 Gene TranscriptionSemantic proximity Read ↗

Polymorphisms in human heat shock factor-1 and analysis of potential biological consequences.Semantic proximity Read ↗

Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis.Semantic proximity Read ↗

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