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Article

Intracellular retention of hepatitis B virus surface protein mutants devoid of amino-terminal pre-S1 sequences.

The Journal of general virology - 1 Feb 1994

Gallina A, De Koning A, Rossi F, Milanesi G

Abstract excerpt

To study the mechanism of L protein-mediated, intracellular (pre-Golgi) retention of hepatitis B virus (HBV) surface proteins, a collection of HBV preS-S open reading frame variants bearing wild-type or modified preS extensions was expressed in human cells. When the secretion phenotype of the corresponding proteins was analysed, all surface proteins with rearranged preS domains were found to be at least partially...

Topics

Base Sequence
Hepatitis B Surface Antigens
Hepatitis B virus
Molecular Sequence Data
Mutation
Open Reading Frames
Protein Precursors
Viral Envelope Proteins

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 8113770
DOI: 10.1099/0022-1317-75-2-449

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8113770-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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