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Article

Investigation of the mechanism of the dominant negative effect of mutations in the tyrosine kinase domain of the insulin receptor.

The EMBO journal - 15 Feb 1994

Levy-Toledano R, Caro L H, Accili D, Taylor S I

Abstract excerpt

Mutations in the tyrosine kinase domain of the insulin receptor cause insulin resistance in a dominant fashion. It has been proposed that formation of hybrid dimers between normal and mutant receptors may explain the dominant negative effect of these mutations. To investigate this mechanism, we expressed two types of human insulin receptors in NIH-3T3 cells; wild type and the tyrosine kinase-deficient Ile1153...

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Identifiers

PMID: 8112298
DOI: 10.1002/j.1460-2075.1994.tb06326.x
PMCID: PMC394882

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Investigation of the mechanism of the dominant negative effect of mutations in the tyrosine kinase domain of the insulin receptor.PMID 8112298Read ↗

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