Investigation of the mechanism of the dominant negative effect of mutations in the tyrosine kinase domain of the insulin receptor.

doi:10.1002/j.1460-2075.1994.tb06326.x

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Article

Investigation of the mechanism of the dominant negative effect of mutations in the tyrosine kinase domain of the insulin receptor.

The EMBO journal - 15 Feb 1994

Levy-Toledano R, Caro L H, Accili D, Taylor S I

Abstract excerpt

Mutations in the tyrosine kinase domain of the insulin receptor cause insulin resistance in a dominant fashion. It has been proposed that formation of hybrid dimers between normal and mutant receptors may explain the dominant negative effect of these mutations. To investigate this mechanism, we e...

Topics

3T3 Cells
Animals
Genes, Dominant
Insulin Receptor Substrate Proteins
Isoleucine
Mice
Mutation
Phosphoproteins
Phosphorylation
Receptor, Insulin
Transfection
Valine

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