Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insulin/IGF-1 hybrid receptors: implications for the dominant-negative phenotype in syndromes of insulin resistance.

Journal of cellular biochemistry - 1 Jan 1992

Frattali A L, Treadway J L, Pessin J E

Abstract excerpt

Classical insulin and IGF-1 receptors are alpha 2 beta 2 heterotetrameric complexes synthesized from two identical alpha beta half-receptor precursors. Recent data strongly suggests, however, that nonidentical alpha beta half-receptor precursors can assemble to generate hybrid holoreceptor species both in vivo and in vitro. This review focuses primarily on two types of hybrid receptors. The first type is an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Insulin
Share to Insulin Resistance
Share to Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Phenotype

Share to Phosphorylation

Share to Protein-Tyrosine Kinases

Share to Receptor, Insulin

Share to Receptors, Cell Surface

Source

Identifiers

PMID: 1316361
DOI: 10.1002/jcb.240480108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insulin/IGF-1 hybrid receptors: implications for the dominant-negative phenotype in syndromes of insulin resistance.PMID 1316361Read ↗

Insulin/IGF-I receptor hybrids: a mechanism for increasing receptor diversity.Semantic proximity Read ↗

Hybrid insulin receptors. Molecular mechanisms of negative-dominant mutations in receptor-mediated insulin resistance.Semantic proximity Read ↗

Human insulin-like growth factor I receptor function in pituitary cells is suppressed by a dominant negative mutant.Semantic proximity Read ↗

Molecular mechanism of insulin resistance in type 2 diabetes mellitus: role of the insulin receptor variant forms.Semantic proximity Read ↗

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and DiseaseSemantic proximity Read ↗

Structural basis by which a recessive mutation in the alpha-subunit of the insulin receptor affects insulin binding.Semantic proximity Read ↗

Investigation of the mechanism of the dominant negative effect of mutations in the tyrosine kinase domain of the insulin receptor.Semantic proximity Read ↗

Rescue of ligand binding of a mutant IGF-I receptor by complementation.Semantic proximity Read ↗

Different ligand affinities of the two human insulin receptor splice variants are reflected in parallel changes in sensitivity for insulin action.Semantic proximity Read ↗

Evidence supporting a passive role for the insulin receptor transmembrane domain in insulin-dependent signal transduction.Semantic proximity Read ↗

Two naturally occurring mutations in the kinase domain of insulin receptor accelerate degradation of the insulin receptor and impair the kinase activity.Semantic proximity Read ↗

High-affinity insulin binding: insulin interacts with two receptor ligand binding sites.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.