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Article

Insulin/IGF-1 hybrid receptors: implications for the dominant-negative phenotype in syndromes of insulin resistance.

Journal of cellular biochemistry - 1 Jan 1992

Frattali A L, Treadway J L, Pessin J E

Abstract excerpt

Classical insulin and IGF-1 receptors are alpha 2 beta 2 heterotetrameric complexes synthesized from two identical alpha beta half-receptor precursors. Recent data strongly suggests, however, that nonidentical alpha beta half-receptor precursors can assemble to generate hybrid holoreceptor specie...

Topics

Animals
Humans
Insulin
Insulin Resistance
Insulin-Like Growth Factor I
Mutation
Phenotype
Phosphorylation
Protein-Tyrosine Kinases
Receptor, Insulin
Receptors, Cell Surface
Receptors, Somatomedin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 1316361
DOI: 10.1002/jcb.240480108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1316361-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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