Molecular mechanism of insulin resistance in type 2 diabetes mellitus: role of the insulin receptor variant forms.

doi:10.1002/dmrr.225

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Article

Molecular mechanism of insulin resistance in type 2 diabetes mellitus: role of the insulin receptor variant forms.

Diabetes/metabolism research and reviews - 1 Jan 2000

Sesti G, Federici M, Lauro D, Sbraccia P, Lauro R

Abstract excerpt

Type 2 diabetes is a heterogeneous and polygenic disorder resulting from interaction of genetic factors with environmental influences. Numerous candidate genes for insulin signaling proteins have been screened, but no single major susceptibility gene for type 2 diabetes has been identified. Due to its pivotal role in insulin action, the insulin receptor was considered a plausible candidate gene. The insulin...

Topics

Alternative Splicing
Animals
Diabetes Mellitus, Type 2
Genetic Variation
Humans
Insulin Resistance
Molecular Structure
Mutation
Polymorphism, Genetic
Protein Isoforms
Protein Multimerization
Receptor, IGF Type 1
Receptor, Insulin

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Open in PubMed

Identifiers

PMID: 11747141
DOI: 10.1002/dmrr.225

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