Article
Two new p73 splice variants, gamma and delta, with different transcriptional activity.
The Journal of experimental medicine - 2 Nov 1998
De Laurenzi V, Costanzo A, Barcaroli D, Terrinoni A, Falco M, Annicchiarico-Petruzzelli M, Levrero M, Melino G
Abstract excerpt
p73 has been recently identified as a new structural and functional homologue of the transcription factor p53. It is expressed in either a full-length form, alpha, or a shorter beta mRNA variant, with exon 13 spliced out. Here we report the identification and functional characterization of two ne...
Topics
- Alternative Splicing
- Amino Acid Sequence
- Apoptosis
- Base Sequence
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- DNA Primers
- DNA-Binding Proteins
- Dimerization
- Genes, Tumor Suppressor
- Genetic Variation
- Humans
- Molecular Sequence Data
- Nuclear Proteins
- Promoter Regions, Genetic