Function of p73, not of p53, is inhibited by the physical interaction with RACK1 and its inhibitory effect is counteracted by pRB.

doi:10.1038/sj.onc.1206382

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Article

Function of p73, not of p53, is inhibited by the physical interaction with RACK1 and its inhibitory effect is counteracted by pRB.

Oncogene - 22 May 2003

Ozaki Toshinori, Watanabe Ken-ichi, Nakagawa Takahito, Miyazaki Kou, Takahashi Masato, Nakagawara Akira

Abstract excerpt

The newly identified p53-related gene, p73, encodes a nuclear transcription factor. Unlike p53, p73 has various isoforms with different NH(2)- and COOH-terminal tails. p73alpha with the longest COOH-terminal extension is most abundantly expressed in many tissues and cells among those splicing isoforms of p73 and the COOH-terminal region appears to have an autoregulatory function. To isolate and characterize the...

Topics

Animals
Apoptosis
COS Cells
DNA-Binding Proteins
GTP-Binding Proteins
Genes, Tumor Suppressor
Humans
Mutation
Neoplasm Proteins
Neoplasms
Nuclear Proteins
Precipitin Tests
Receptors for Activated C Kinase

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Cell Surface

Retinoblastoma Protein

Transcriptional Activation

Tumor Cells, Cultured

Tumor Protein p73

Source

Open in PubMed

Identifiers

PMID: 12761493
DOI: 10.1038/sj.onc.1206382

Genes

RACK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.