Article
Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning.
Nature - 3 Feb 1994
Cremer H, Lange R, Christoph A, Plomann M, Vopper G, Roes J, Brown R, Baldwin S, Kraemer P, Scheff S
Abstract excerpt
Neural-cell adhesion molecules (N-CAMs) are members of the immunoglobulin superfamily mediating homo- and heterophilic cell-cell interactions. N-CAM exists in various isoforms which are generated by alternative splicing. During embryonic development, N-CAMs are expressed in derivatives of all thr...
Topics
- Animals
- Base Sequence
- Cell Adhesion Molecules, Neuronal
- Cell Line
- DNA Primers
- Embryo, Mammalian
- Heterozygote
- Homozygote
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data
- Mutation
- Olfactory Bulb
- Sialic Acids
- Spatial Behavior