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Mice Mutated in the First Fibronectin Domain of Adhesion Molecule L1 Show Brain Malformations and Behavioral Abnormalities.

Biomolecules - 11 Apr 2024

Granato Viviana, Congiu Ludovica, Jakovcevski Igor, Kleene Ralf, Schwindenhammer Benjamin, Fernandes Luciana, Freitag Sandra, Schachner Melitta, Loers Gabriele

Abstract excerpt

The X-chromosome-linked cell adhesion molecule L1 (L1CAM), a glycoprotein mainly expressed by neurons in the central and peripheral nervous systems, has been implicated in many neural processes, including neuronal migration and survival, neuritogenesis, synapse formation, synaptic plasticity and regeneration. L1 consists of extracellular, transmembrane and cytoplasmic domains. Proteolytic cleavage of L1's...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38672483
DOI: 10.3390/biom14040468
PMCID: PMC11048097

Genes

MBP
L1CAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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