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Article

Role of neural cell adhesion molecule and polysialic acid in mouse circadian clock function.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jul 1997

Shen H, Watanabe M, Tomasiewicz H, Rutishauser U, Magnuson T, Glass J D

Abstract excerpt

The suprachiasmatic nuclei (SCN) express the highly polysialylated form of the neural cell adhesion molecule (NCAM) that has been proposed to promote plasticity in the adult brain. To investigate a role for NCAM in SCN circadian clock function, we examined the daily locomotor rhythm of mice homozygous for a mutation, Ncamtm1Cwr, which results in deletion of the NCAM-180 isoform that in brain carries polysialic...

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PMID: 9185559
PMCID: PMC6573300

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