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Spatiotemporal processing of neural cell adhesion molecules 1 and 2 by BACE1 in vivo

1 Jan 2021

Abstract excerpt

Neural cell adhesion molecules 1 (NCAM1) and 2 (NCAM2) belong to the cell adhesion molecules of the immunoglobulin superfamily and have been shown to regulate formation, maturation, and maintenance of synapses. NCAM1 and NCAM2 undergo proteolysis, but the identity of all the proteases involved and how proteolysis is used to regulate their functions are not known. We report here that NCAM1 and NCAM2 are BACE1...

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PMID: 33548223
DOI: 10.1016/j.jbc.2021.100372

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