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Article

Behavioural effects of extracellular matrix protein Fras1 depletion in the mouse.

The European journal of neuroscience - 1 Jun 2021

Kalpachidou Theodora, Makrygiannis Apostolos K, Pavlakis Evangelos, Stylianopoulou Fotini, Chalepakis Georges, Stamatakis Antonios

Abstract excerpt

Fras1 is an extracellular protein of the basement membranes that surround embryonic epithelia, choroid plexuses and meninges in foetal mouse brain. Depletion of Fras1 in knockout mice results in sub-epidermal blistering and fusion of eyelids and digits as well as malformation of lungs and kidneys. Mutations in the human counterpart FRAS1 are responsible for the Fraser Syndrome with clinical manifestations similar...

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Source

Identifiers

PMID: 32333816
DOI: 10.1111/ejn.14759

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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