Neuronal cell adhesion molecule deletion induces a cognitive and behavioral phenotype reflective of impulsivity.

doi:10.1111/j.1601-183X.2007.00382.x

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Article

Neuronal cell adhesion molecule deletion induces a cognitive and behavioral phenotype reflective of impulsivity.

Genes, brain, and behavior - 1 Jun 2008

Matzel L D, Babiarz J, Townsend D A, Grossman H C, Grumet M

Abstract excerpt

Cell adhesion molecules, such as neuronal cell adhesion molecule (Nr-CAM), mediate cell-cell interactions in both the developing and mature nervous system. Neuronal cell adhesion molecule is believed to play a critical role in cell adhesion and migration, axonal growth, guidance, target recognition and synapse formation. Here, wild-type, heterozygous and Nr-CAM null mice were assessed on a battery of five...

Topics

Animals
Avoidance Learning
Behavior, Animal
Brain
Brain Chemistry
CD56 Antigen
Cognition
Cognition Disorders
Disease Models, Animal
Exploratory Behavior
Fear
Female
Genetic Predisposition to Disease
Impulsive Behavior
Male

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Open in PubMed

Identifiers

PMID: 18081712
DOI: 10.1111/j.1601-183X.2007.00382.x

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