Article
A temperature-conditional mutant of simian virus 40 large T antigen requires serum to inhibit myogenesis and does not induce DNA synthesis in myotubes.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Feb 1997
Salvatori G, Lattanzi L, Puri P L, Melchionna R, Fieri C, Levrero M, Molinaro M, Cossu G
Abstract excerpt
The temperature-conditional mutant tsA58 of SV40 large T antigen (Tag) increases the proliferation rate and the number of cell divisions in primary murine and human myogenic cells when expressed under permissive conditions (i.e., at 33 degrees C in medium containing high levels of serum). Under t...
Topics
- Animals
- Antigens, Polyomavirus Transforming
- Blood Proteins
- Cell Differentiation
- Cell Division
- Cell Line
- Cells, Cultured
- Culture Media, Conditioned
- DNA
- Growth Inhibitors
- Humans
- Mice
- Muscle Development
- Muscle, Skeletal