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Article

A dominant negative mutant of PMA1 interferes with the folding of the wild type enzyme.

Traffic (Copenhagen, Denmark) - 1 Jan 2010

Eraso Pilar, Mazón María J, Portillo Francisco

Abstract excerpt

Misfolded proteins are usually arrested in the endoplasmic reticulum (ER) and degraded by the ER-associated degradation (ERAD) machinery. Several mutant alleles of PMA1, the gene coding for the plasma membrane H (+)-ATPase, render misfolded proteins that are subjected to ERAD. A subset of misfolded PMA1 mutants exhibits a dominant negative effect on yeast growth since, when co-expressed with the wild type allele,...

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Source

Identifiers

PMID: 19929866
DOI: 10.1111/j.1600-0854.2009.01005.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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